GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12196860 | 1 | rs12209192 | chr6:55967702 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12209420 | chr6:55937876 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.91 | 8.37E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12209464 | chr6:55985189 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.81 | 1.58E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12209509 | chr6:55962183 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12209529 | chr6:55932278 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs12216499 | 1 | rs12210218 | chr6:159377219 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.68 | 0.000249 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12196860 | 1 | rs12210228 | chr6:55973083 | COL21A1 | chr6:55921389-56258892:- | -0.36 | -6.71 | 3.25E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12210402 | chr6:55943418 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.95 | 6.57E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12210468 | chr6:55934393 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12211223 | chr6:55959848 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.89 | 9.52E-12 | Psychosis (atypical) |
| BRCA | cis | rs2274459 | 1 | rs12211490 | chr6:33725528 | IP6K3 | chr6:33689443-33714762:- | 0.26 | 4.49 | 8.06E-6 | Obesity (extreme) |
| BRCA | cis | rs2274459 | 1 | rs12211554 | chr6:33725788 | IP6K3 | chr6:33689443-33714762:- | 0.26 | 4.41 | 1.13E-5 | Obesity (extreme) |
| BRCA | cis | rs2274459 | 1 | rs12211565 | chr6:33725852 | IP6K3 | chr6:33689443-33714762:- | 0.26 | 4.49 | 8.06E-6 | Obesity (extreme) |
| BRCA | cis | rs12196860 | 1 | rs12211619 | chr6:56014005 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.89 | 9.79E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12212032 | chr6:56005703 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.92 | 7.55E-12 | Psychosis (atypical) |